Course: Immunoinformatics and nanovaccines
Duration: 6 weeks
Course start: April 04, 2022
Modality: Online
Spanish Language
En proceso de registro en STPS y SEP-CONOCER
about the course
TEMARY
In this course the student will learn basic immunology concepts focused on the development of epitopic vaccines for humoral and cellular immunity. Concepts of protein structures will be reviewed. In addition, it will be done with the Spike protein of COVID19 to identify immunogenic regions. For this, linear and conformational epitope predictors for MHC-I and MHC-II will be used, molecular coupling studies with MHC will be made. In addition, assisted exercise will be left to do a coupling with the nanoparticle, in this case the PAMAM-G4 dendrimer.
Innate and adaptive immunity
Peptide recognition by MHC
MHC-Peptides-TCR
QSAR studies at MHC
Criteria for selection of antigenic protein
Sequence search and multiple alignment to obtain consensus sequence
Tertiary structure, construction and obtaining PDB
Evaluation of a tertiary structure and minimization
Prediction of linear epitopes and immunoproteosome
Conformational epitope prediction
Obtaining epitopes using protein-antibody complexes
Construction and third dimension and structural refinement of epitopes
Coupling studies on MHC-I and MHCII
Dendrimers as peptide nanocarriers
Peptide-dendrimer coupling study
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